Accelerated Bone Healing with 660 nm Low-Level Laser Therapy and Bone Marrow Coagulation
Study Overview
Description: This study evaluated the effects of bone marrow aspirate (BMA) and low-level laser therapy (LLLT) on bone healing. Critical-size defects were created in rat calvaria and divided into four groups to observe bone healing under different treatment protocols.
Participants: 64 rats, in whose calvaria 5 mm diameter critical-size defects were created.
Intervention: The rats were randomly divided into four groups:
Control: Treated with a blood clot only.
BMA: Treated with coagulated bone marrow aspirate.
LLLT: Treated with laser irradiation and a blood clot.
BMA/LLLT: Treated with laser irradiation and coagulated bone marrow aspirate.
Methods: The rats were euthanized at 15 or 30 days postoperative to evaluate bone healing.
Conclusion: This study demonstrated that bone marrow coagulated and low-level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization.
